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Engineered T cells: the promise and challenges of ... - Nature

23 Aug 2016 ... Recent clinical trials using T cells engineered to express chimeric antigen receptors (CARs) or engineered T cell receptors (TCRs) have...

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Genetically engineered T cells for cancer immunotherapy ...

20 Sep 2019 ... Chimeric antigen receptor-modified T (CAR-T) cells, which are genetically engineered to express CAR molecules targeting surface antigens on...

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Engineered T cells: the promise and challenges of ... - PubMed

Engineered T cells: the promise and challenges of cancer immunotherapy. Nat Rev Cancer. 2016 Aug 23;16(9):566-81. doi: 10.1038/nrc.2016.97.

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Engineered T Cells: The Promise and ... - NCBI - NIH

23 Aug 2017 ... Comparing basic structure of engineered T cell receptors and chimeric antigen receptors. Endogenous T cell receptors include paired alpha and...

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Engineered T Cell Therapy for Cancer in the Clinic ... - Frontiers

11 Oct 2019 ... T cells play a key role in cell-mediated immunity, and strategies to genetically modify T cells, including chimeric antigen receptor (CAR) T cell...

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CRISPR-engineered T cells in patients with refractory cancer ...

28 Feb 2020 ... The infusion of ex vivo engineered T cells, termed adoptive T cell therapy, can increase the natural antitumor immune response of the patient.

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Reversal of exhaustion in engineered T cells | Science

2 Apr 2021 ... A similar outcome may occur in therapeutic T cells engineered with synthetic chimeric antigen receptors (CARs), which bypass the native TCR...

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T cell receptor-engineered T cells for leukemia ...

3 Jan 2019 ... Clinical trials involving chimeric antigen receptor-engineered T cells have been a major breakthrough and became a novel therapy for leukemia.

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Thermal Control of Engineered T-cells | ACS Synthetic Biology

30 Jul 2020 ... Genetically engineered T-cells are being developed to perform a variety of therapeutic functions. However, no robust mechanisms exist to...

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Chimeric antigen receptor T cell - Wikipedia

Chimeric antigen receptor T cells are T cells that have been genetically engineered to produce an artificial T-cell receptor for use in immunotherapy. Chimeric...

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TCR-engineered T cells to treat tumors: Seeing but not ...

Adoptive transfer of T cells gene-engineered with T cell receptors (TCRs) has proven its feasibility and therapeutic potential in the treatment of malignant tumors.

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The Anticancer Potential of T Cell Receptor ... - X-MOL

2020年9月26日 ... Adoptively transferred T cell receptor (TCR)-transgenic T cells (TCR-T cells) ... The Anticancer Potential of T Cell Receptor-Engineered T Cells

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(PDF) CRISPR-engineered T cells in patients with refractory ...

6 Dec 2020 ... PDF | CRISPR-Cas9 gene editing provides a powerful tool to enhance the natural ability of human T cells to fight cancer. We report a...

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In vivo therapeutic effects of affinity-improved-TCR engineered ...

Background In patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), virus-specific cytotoxic T lymphocytes (CTLs) fail to eliminate HCC...

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Cancer immunotherapy using T-cell receptor engineered T ...

25 Mar 2020 ... Keywords: Adoptive cellular therapy (ACT); T-cell receptor engineered T-cell therapy (TCR-T); tumor antigen; combination therapy...

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Engineered T-Cells: A look at Autologous and Allogeneic CAR ...

12 Jun 2020 ... One of the most revolutionary approaches to date is chimeric antigen receptor (CAR) T cell therapy, a type of personalized therapy where the...

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Optimized tandem CD19/CD20 CAR-engineered T cells in ...

1 Oct 2020 ... Chimeric antigen receptor (CAR) T cells are effective therapies for relapsed/refractory B-cell malignancies. However, relapses occur, often in...

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Engineered T cells: the promise and challenges of ... - Nature

23 Aug 2016 ... Recent clinical trials using T cells engineered to express chimeric antigen receptors (CARs) or engineered T cell receptors (TCRs) have...

Get Price

Genetically engineered T cells for cancer immunotherapy ...

20 Sep 2019 ... Chimeric antigen receptor-modified T (CAR-T) cells, which are genetically engineered to express CAR molecules targeting surface antigens on...

Get Price

Engineered T cells: the promise and challenges of ... - PubMed

Engineered T cells: the promise and challenges of cancer immunotherapy. Nat Rev Cancer. 2016 Aug 23;16(9):566-81. doi: 10.1038/nrc.2016.97.

Get Price

Engineered T Cells: The Promise and ... - NCBI - NIH

23 Aug 2017 ... Comparing basic structure of engineered T cell receptors and chimeric antigen receptors. Endogenous T cell receptors include paired alpha and...

Get Price

Engineered T Cell Therapy for Cancer in the Clinic ... - Frontiers

11 Oct 2019 ... T cells play a key role in cell-mediated immunity, and strategies to genetically modify T cells, including chimeric antigen receptor (CAR) T cell...

Get Price

CRISPR-engineered T cells in patients with refractory cancer ...

28 Feb 2020 ... The infusion of ex vivo engineered T cells, termed adoptive T cell therapy, can increase the natural antitumor immune response of the patient.

Get Price

Reversal of exhaustion in engineered T cells | Science

2 Apr 2021 ... A similar outcome may occur in therapeutic T cells engineered with synthetic chimeric antigen receptors (CARs), which bypass the native TCR...

Get Price

T cell receptor-engineered T cells for leukemia ...

3 Jan 2019 ... Clinical trials involving chimeric antigen receptor-engineered T cells have been a major breakthrough and became a novel therapy for leukemia.

Get Price

Thermal Control of Engineered T-cells | ACS Synthetic Biology

30 Jul 2020 ... Genetically engineered T-cells are being developed to perform a variety of therapeutic functions. However, no robust mechanisms exist to...

Get Price

Chimeric antigen receptor T cell - Wikipedia

Chimeric antigen receptor T cells are T cells that have been genetically engineered to produce an artificial T-cell receptor for use in immunotherapy. Chimeric...

Get Price

engineered t cells - 英中– Linguee词典

大量翻译例句关于"engineered t cells" – 英中词典以及8百万条中文译文例句 ... Genetic engineered material is transported to tumor cells by viruses that infect...

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Engineered T Cells for the Adoptive Therapy of B-Cell Chronic ...

Adoptive T cell therapy with genetically engineered specificity is thought to fulfil expectations, and clinical trials for the treatment of CLL are initiated. Cytolytic T...

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CARs and TRUCKs: how engineered T cells become living ...

T cell cancer. T cells with engineered pre-defined specificity. T cell cancer cell. The aim: To give patient´s immune cells specificity for targeting autologous...

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GMP-engineered T cells | T cells | Applications | Miltenyi ...

Automated manufacturing of GMP engineered T cells – separation, activation, transduction, and expansion in a single closed system. | France.

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Genetically engineered T cells could lead to therapies for ...

3 Dec 2020 ... Immunobiologists have created a five-module chimeric antigen receptor T cell that is showing early potential to fight Type 1 diabetes.

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WO2016113203A1 - Engineered t cells and uses therefor ...

WO2016113203A1 - Engineered t cells and uses therefor - Google Patents ... 210000001744 T-Lymphocytes Anatomy 0.000 claims abstract description 134...

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TCR-engineered T-cell therapy through personalized ...

25 May 2020 ... e15021Background: T-cell receptor (TCR)-engineered T cells are a novel option for adoptive cell therapy used for the treatment of several...

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Adoptive Cell Therapy: CAR T, TCR, TIL, NK – Cancer ...

How Cellular Immunotherapies Are Changing the Outlook for Cancer Patients · Tumor-Infiltrating Lymphocyte (TIL) Therapy · Engineered T Cell Receptor (TCR)...

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Engineered cell therapies | BioNTech

For that purpose, T cells are mostly engineered to express either T cell receptors, or TCRs, or chimeric antigen receptors, or CARs. Recently, CAR expressing T...

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CAR T Cells: Engineering Immune Cells to Treat Cancer ...

30 Jul 2019 ... Once the collected T cells have been engineered to express the antigen-specific CAR, they are "expanded" in the laboratory into the hundreds of...

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